Currently, Professor Flint is a member of the Department of Psychiatry of the University of California Los Angeles, having worked previously at the Wellcome Trust Centre for Human Genetics, in Oxford. He has made numerous and very important scientific contributions, including the identification of the first replicated genetic loci contributing for susceptibility to major depression. For that, Professor Jonathan worked with Chinese colleagues in order to access a vast cohort of case-controls with major recurring depression, in which all subjects were entirely phenotyped. His analysis led to the identification of two replicated loci related to major depression and to the discovery that, in these cases, subjects had a bigger quantity of mitochondrial DNA than controls.
A better diagnosing ability and the development of new therapies for this high-morbidity disease: these are the goals of Professor Flint’s research. Given the impact of a disorder like depression in the quality of a patient’s life, this research is and will certainly continue to be key in a much needed change of paradigm regarding the subject.