iMed Sessions | Sonia Trigueros

Sonia Trigueros, natural from Barcelona, Spain, obtained her Bachelor in Biology, at the University of Barcelona, in 1995. In the two following years she acquired her Master’s degree in Biotechnology, at the same University, and in 2002, she obtained her PhD in Molecular Genetics.

Her first Postdoctoral Research (2001-2004) was in Molecular Biology Research Laboratory, coordinated by Professor James C. Wang, in the Department of Molecular and Cellular Biology MCB, at Harvard University, USA. In 2004‐2007, she developed another postdoctoral research at the Laboratory of Professor David Sherratt in the Microbiology Unit of the Department of Biochemistry, at the University of Oxford, UK. At the same University, she developed her Senior Research Postdoc, between 2007 and 2008, in Bionanotechnology, at the Department of Physics.

Nanotechnology is a new exciting field that has the potential to transform the way that medical and healthcare solutions are being developed.Sonia Trigueros

Between 2009 and 2010, she was a Research Fellow, at Oxford Martin Institute of Nanoscience for Medicine and in the Department of Physics, at the University of Oxford, UK. At the same department, her Senior Research Fellowship was between April 2010 and September 2012. Currently, since September 2012, Sonia Trigueros is an Academic Fellow. She is also a visiting professor at the University of Havana, Cuba, since 2009. Currently, Sonia Trigueros is developing six different projects: Basic Research on DNA molecular motors-drug interaction,  Smart NanoSystems,  Monitoring cell-nanoparticles effects, Mechanisms of cell-nano-particle interaction, Nano-Gene-Delivery System and the Development of a novel method for generation of attenuated bacteria vaccines by in vivo DNA condensation.

SESSION PREVIEW

​Sonia Trigueros’ current research focuses on the design of novel nanostructures to target DNA Biomolecular Motors – DNA topoisomerases and DNA translocases – and particular DNA conformational states in dividing cells, particularly in cancer cells.

DNA topoisomerases’ activity allows cells to modulate the degree of supercoiling, knotting and catenation of DNA strands. By biochemical and genetic manipulation of these enzymes, we can alter the intracellular DNA topology and study its effect on chromosome activities and DNA organization. This topoisomerases are important targets of pharmacology: eukaryotic DNA topoisomerases are the targets of chemotherapy drugs, and prokaryotic DNA topoisomerases, on the other hand, are the targets of several antibiotics.

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